Diversity of Methodologies to Study Huntington Disease Pathogenesis

Samuel Gunderson (Molecular Biology and Biochemistry)
Alice Liu (Cell Biology and Neuroscience)

Huntington’s Disease (HD) is a horrific familial neurodegenerative disease controlled by a single mutant gene called the mutant Huntington’s (mHtt) gene that is transmitted in an autosomal-dominant mode. The mutation that causes HD is the expansion of a DNA sequence (CAG repeats) within the 1st exon of the Htt gene which codes of an extended stretch of glutamine residues (Q) in the mHtt protein. The pathogenic mechanism of mHtt is not clear. The aim of this seminar is to learn the basics of biological information flow. Within this context, we will learn and discuss the cause and role of mHtt protein aggregation and pathogenic transcript processing that result in cellular dysfunction.

Course Number: 
01:090:101 section AB index 11048